By Donald Huddler,Edward R. Zartler
Applied Biophysics for Drug Discovery is a consultant to new ideas and techniques to selecting and characterizing small molecules in early drug discovery. Biophysical equipment are reasserting their software in drug discovery and during a mixture of the increase of fragment-based drug discovery and an elevated specialize in extra nuanced characterisation of small molecule binding, those equipment are enjoying an expanding position in discovery campaigns.
This textual content emphasizes sensible concerns for choosing and deploying middle biophysical approach, together with yet now not restricted to ITC, SPR, and either ligand-detected and protein-detected NMR.
Topics coated include:
• layout concerns in biophysical-based lead screening
• Thermodynamic characterization of protein-compound interactions
• Characterizing pursuits and screening reagents with HDX-MS
• Microscale thermophoresis tools (MST)
• Screening with susceptible Affinity Chromatography
• the way to investigate compound place of abode time
• 1D-NMR tools for hit identification
• Protein-based NMR tools for SAR development
• case reviews integrating a number of biophysical methods
This textual content is perfect for educational investigators and scientists making plans hit characterization campaigns or designing and optimizing screening strategies.
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Applied Biophysics for Drug Discovery by Donald Huddler,Edward R. Zartler